Knoevenagel reaction
This involves the condensation of a carbonyl compound (aldehyde or ketone) with an active methylene compound of the type Z-CH2-Z'. This classical reaction is usually catalyzed by organic bases (primary, secondary and tertiary amines), ammonia and ammonium salts or by Lewis acids such as CuCl, ZnCl2 and SmI.
It is widely used in the synthesis of intermediates or end-products for perfumes, pharmaceuticals and polymers.
The reaction between acetaldehyde and esters can be readily catalyzed by macroreticular weak base polymeric catalyst (Amberlyst™ A21).
Recommended Catalyst
| Amberlyst™ A21 |
Macroreticular weakly basic polymeric catalyst |
For sampling, pricing and availability of AMBERLYSTT catalysts please contact your Rohm and Haas sales representative.
